Implant Osseointegration and the Role of Microroughness and Nanostructures: Lessons for Spine Implants
Identifieur interne : 001998 ( Main/Exploration ); précédent : 001997; suivant : 001999Implant Osseointegration and the Role of Microroughness and Nanostructures: Lessons for Spine Implants
Auteurs : Rolando A. Gittens [États-Unis] ; Rene Olivares-Navarrete [États-Unis] ; Zvi Schwartz [États-Unis] ; Barbara D. Boyan [États-Unis]Source :
- Acta biomaterialia [ 1742-7061 ] ; 2014.
Abstract
The use of spinal implants for spine fusion has been steadily increasing to avoid the risks of complications and donor site morbidity involved when using autologous bone. A variety of fusion cages are clinically available, with different shapes and chemical compositions. However, detailed information about their surface properties and the effects of such properties on osteogenesis is lacking in the literature. Here we evaluate the role of surface properties for spinal implant applications, covering some of the key biological processes that occur around an implant and focusing on the role of surface properties, specifically surface structure, on osseointegration, drawing examples from other implantology fields when required. Our findings revealed that surface properties such as micro-roughness and nanostructures can directly affect early cell behavior and long-term osseointegration. Micro-roughness has been well established in the literature to have a beneficial effect on osseointegration of implants. In the case of the role of nanostructures, the number of reports is increasing and most studies reveal a positive effect from the nanostructures alone and a synergistic effect when combined with micro-rough surfaces. Still, long-term clinical results are necessary to establish the full implications of surface nanomodifications.
Url:
DOI: 10.1016/j.actbio.2014.03.037
PubMed: 24721613
PubMed Central: 4103432
Affiliations:
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Gittens</name><affiliation wicri:level="2"><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation><nlm:aff id="A3">Center for Biodiversity and Drug Discovery, Institute for Scientific Research and High Technology Services (INDICASAT-AIP), Panama, Republic of Panama</nlm:aff><wicri:noCountry code="subfield">Republic of Panama</wicri:noCountry></affiliation></author><author><name sortKey="Olivares Navarrete, Rene" sort="Olivares Navarrete, Rene" uniqKey="Olivares Navarrete R" first="Rene" last="Olivares-Navarrete">Rene Olivares-Navarrete</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Schwartz, Zvi" sort="Schwartz, Zvi" uniqKey="Schwartz Z" first="Zvi" last="Schwartz">Zvi Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A2">Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><affiliation wicri:level="2"><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Acta biomaterialia</title><idno type="ISSN">1742-7061</idno><idno type="eISSN">1878-7568</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The use of spinal implants for spine fusion has been steadily increasing to avoid the risks of complications and donor site morbidity involved when using autologous bone. A variety of fusion cages are clinically available, with different shapes and chemical compositions. However, detailed information about their surface properties and the effects of such properties on osteogenesis is lacking in the literature. Here we evaluate the role of surface properties for spinal implant applications, covering some of the key biological processes that occur around an implant and focusing on the role of surface properties, specifically surface structure, on osseointegration, drawing examples from other implantology fields when required. Our findings revealed that surface properties such as micro-roughness and nanostructures can directly affect early cell behavior and long-term osseointegration. Micro-roughness has been well established in the literature to have a beneficial effect on osseointegration of implants. In the case of the role of nanostructures, the number of reports is increasing and most studies reveal a positive effect from the nanostructures alone and a synergistic effect when combined with micro-rough surfaces. Still, long-term clinical results are necessary to establish the full implications of surface nanomodifications.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Virginie</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Gittens, Rolando A" sort="Gittens, Rolando A" uniqKey="Gittens R" first="Rolando A." last="Gittens">Rolando A. Gittens</name></region><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><name sortKey="Gittens, Rolando A" sort="Gittens, Rolando A" uniqKey="Gittens R" first="Rolando A." last="Gittens">Rolando A. Gittens</name><name sortKey="Olivares Navarrete, Rene" sort="Olivares Navarrete, Rene" uniqKey="Olivares Navarrete R" first="Rene" last="Olivares-Navarrete">Rene Olivares-Navarrete</name><name sortKey="Schwartz, Zvi" sort="Schwartz, Zvi" uniqKey="Schwartz Z" first="Zvi" last="Schwartz">Zvi Schwartz</name><name sortKey="Schwartz, Zvi" sort="Schwartz, Zvi" uniqKey="Schwartz Z" first="Zvi" last="Schwartz">Zvi Schwartz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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